References
Dogs and Cats
- Saito M, Takahashi KA, Arai Y, et al. Intraarticular administration of platelet-rich plasma with biodegradable gelatin hydrogel microspheres prevents osteoarthritis progression in the rabbit knee. Clin Exp Rheumatol. 2009;27(2):201-207
Horses
- Smith PA. Intra-articular autologous conditioned plasma injections provide safe and efficacious treatment for knee osteoarthritis: an FDA-sanctioned, randomized, double-blind, placebo-controlled clinical trial. Am J Sports Med. 2016;44(4):884-891. doi:10.1177/0363546515624678
- Arthrex, Inc. Data on file (APT-5368). Naples, FL; 2021.
- Hraha TH, Doremus KM, McIlwraith CW, Frisbie DD. Autologous conditioned serum: the comparative cytokine profiles of two commercial methods (IRAP and IRAP II) using equine blood. Equine Vet J. 2011;43(5):516-521. doi:10.1111/j.2042-3306.2010.00321.x
- Lasarzik J, Bondzio A, Rettig M, et al. Evaluation of two protocols using autologous conditioned serum for intra-articular therapy of equine osteoarthritis: a pilot study monitoring cytokines and cartilage-specific biomarkers. J Equine Vet Sci. 2018;60:35-42.e2. doi:10.1016/j.jevs.2016.09.014
- Frisbie DD, Kawcak CE, Werpy NM, Park RD, McIlwraith CW. Clinical, biochemical, and histologic effects of intra-articular administration of autologous conditioned serum in horses with experimentally induced osteoarthritis. Am J Vet Res. 2007;68(3):290-296. doi:10.2460/ajvr.68.3.290
- Arthrex, Inc. Data on file (APT15519). Naples, FL; 2022.
Knee Injuries
- Cook JL, Luther JK, Beetem J, Karnes J, Cook CR. Clinical comparison of a novel extracapsular stabilization procedure and tibial plateau leveling osteotomy for treatment of cranial cruciate ligament deficiency in dogs. Vet Surg. 2010;39(3):315-323. doi:10.1111/j.1532-950X.2010.00658.x
- Christopher SA, Beetem J, Cook JL. Comparison of long-term outcomes associated with three surgical techniques for treatment of cranial cruciate ligament disease in dogs. Vet Surg. 2013;42(3):329-334. doi:10.1111/j.1532-950X.2013.12001.x
Arthritis
- Saito M, Takahashi KA, Arai Y, et al. Intraarticular administration of platelet-rich plasma with biodegradable gelatin hydrogel microspheres prevents osteoarthritis progression in the rabbit knee. Clin Exp Rheumatol. 2009;27(2):201-207
- Franklin SP, Cook JL. Prospective trial of autologous conditioned plasma versus hyaluronan plus corticosteroid for elbow osteoarthritis in dogs. Can Vet J. 2013;54(9):881-884
- Gines JA. Effect of leukoreduced platelet rich plasma on intra-articular pro-inflammatory cytokines in a canine pilot study. Animals (Basel). 2022;12(17):2163. Published 2022 Aug 24. doi:10.3390/ani12172163
- Eppley BL, Woodell JE, Higgins J. Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plast Reconstr Surg. 2004;114(6):1502-1508. doi:10.1097/01.prs.0000138251.07040.51
- Smith PA. Intra-articular autologous conditioned plasma injections provide safe and efficacious treatment for knee osteoarthritis: an FDA-sanctioned, randomized, double-blind, placebo-controlled clinical trial. Am J Sports Med. 2016;44(4):884-891. doi:10.1177/0363546515624678
- Hraha TH, Doremus KM, McIlwraith CW, Frisbie DD. Autologous conditioned serum: the comparative cytokine profiles of two commercial methods (IRAP and IRAP II) using equine blood. Equine Vet J. 2011;43(5):516-521. doi:10.1111/j.2042-3306.2010.00321.x
CCL Treatment
- Jeong J, Jeong SM, Kim SE, Lewis DD, Lee H. Subsequent meniscal tears following tibial tuberosity advancement and tibial plateau leveling osteotomy in dogs with cranial cruciate ligament deficiency: an in vivo experimental study. Vet Surg. 2021;50(5):966-974. doi:10.1111/vsu.13648
- Beer P, Bockstahler B, Schnabl-Feichter E. Tibial plateau leveling osteotomy and tibial tuberosity advancement – a systematic review. Tierarztl Prax Ausg K Kleintiere Heimtiere. 2018;46(4):223-235. doi:10.15654/TPK-170486
- Moore EV, Weeren R, Paek M. Extended long-term radiographic and functional comparison of tibial plateau leveling osteotomy vs tibial tuberosity advancement for cranial cruciate ligament rupture in the dog. Vet Surg. 2020;49(1):146-154. doi:10.1111/vsu.13277
- Christopher SA, Beetem J, Cook JL. Comparison of long-term outcomes associated with three surgical techniques for treatment of cranial cruciate ligament disease in dogs. Vet Surg. 2013;42(3):329-334. doi:10.1111/j.1532-950X.2013.12001.
- Husi B, Park B, Lampart M, Evans R, Pozzi A. Comparative kinetic and kinematic evaluation of TPLO and TPLO combined with extra-articular lateral augmentation: A biomechanical study. Vet Surg. 2023;52(5):686-696. doi:10.1111/vsu.13955
- Cook JL, Luther JK, Beetem J, Karnes J, Cook CR. Clinical comparison of a novel extracapsular stabilization procedure and tibial plateau leveling osteotomy for treatment of cranial cruciate ligament deficiency in dogs. Vet Surg. 2010;39(3):315-323. doi:10.1111/j.1532-950X.2010.00658.x
- Redolfi G, Grand JG. Complications and Long-Term Outcomes after Combined Tibial Plateau Leveling Osteotomy and Tibial Tuberosity Transposition for Treatment of Concurrent Cranial Cruciate Ligament Rupture and Grade III or IV Medial Patellar Luxation. Vet Comp Orthop Traumatol. 2024;37(1):43-49. doi:10.1055/s-0043-1770740
- Varhus JD. A novel bioelectric device enhances wound healing: an equine case series. J Equine Vet Sci. 2014;34(3):421‑430. doi:10.1016/j.jevs.2013.07.011
- Kim H, Makin I, Skiba J, et al. Antibacterial efficacy testing of a bioelectric wound dressing against clinical wound pathogens. Open Microbiol J. 2014;8:15-21. doi:10.2174/1874285801408010015
- Nurden AT, Nurden P, Sanchez M, Andia I, Anitua E. Platelets and wound healing. Front Biosci. 2008;13:3532-3548. doi:10.2741/2947
- Carter CA, Jolly DG, Worden CE Sr, Hendren DG, Kane CJ. Platelet-rich plasma gel promotes differentiation and regeneration during equine wound healing. Exp Mol Pathol. 2003;74(3):244-255. doi:10.1016/s0014-4800(03)00017-0
Arthritis Treatment
- Smith PA. Intra-articular autologous conditioned plasma injections provide safe and efficacious treatment for knee osteoarthritis: an FDA-sanctioned, randomized, double-blind, placebo-controlled clinical trial. Am J Sports Med. 2016;44(4):884-891
- Georg R, Maria C, Gisela A, Bianca C. Autologous conditioned plasma as therapy of tendon and ligament lesions in seven horses. J Vet Sci. 2010;11(2):173-175. doi:10.4142/jvs.2010.11.2.173
- Anitua E, Sanchez M, Nurden AT, et al. Platelet-released growth factors enhance the secretion of hyaluronic acid and induce hepatocyte growth factor production by synovial fibroblasts from arthritic patients. Rheumatology (Oxford). 2007;46(12):1769-1772. doi:10.1093/rheumatology/kem234
- Arthrex, Inc. Data on file (APT-5368). Naples, FL; 2021.
- Hraha TH, Doremus KM, McIlwraith CW, Frisbie DD. Autologous conditioned serum: the comparative cytokine profiles of two commercial methods (IRAP and IRAP II) using equine blood. Equine Vet J. 2011;43(5):516-521. doi:10.1111/j.2042-3306.2010.00321.x

